| Pitching | G | GS | W | L | SV | BS | HLD | CG | SHO | IP | H | R | ER | HR | BB | K | ERA | WHIP | BAA |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Totals | 232 | 130 | 118 | 28 | 109 | 266 | 4.27 | 1.37 | .245 | ||||||||||
| League Rank | 16 | 23 | 22 | T13 | 25 | 30 | 21 | T21 | T12 | ||||||||||
| Jose De La Torre | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.00 | 0.00 | .000 |
| Andrew Bailey | 6 | 0 | 0 | 0 | 3 | 0 | 2 | 0 | 0 | 6.0 | 1 | 0 | 0 | 0 | 3 | 10 | 0.00 | 0.67 | .053 |
| Alex Wilson | 11 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 11.1 | 10 | 2 | 2 | 0 | 7 | 9 | 1.59 | 1.50 | .233 |
| Craig Breslow | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.0 | 4 | 2 | 1 | 0 | 1 | 2 | 2.25 | 1.25 | .235 |
| Clay Buchholz | 5 | 5 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 34.2 | 25 | 9 | 9 | 2 | 12 | 40 | 2.34 | 1.07 | .202 |
| Koji Uehara | 12 | 0 | 0 | 0 | 1 | 1 | 5 | 0 | 0 | 10.2 | 9 | 3 | 3 | 2 | 2 | 18 | 2.53 | 1.03 | .220 |
| Junichi Tazawa | 14 | 0 | 2 | 1 | 0 | 2 | 7 | 0 | 0 | 14.0 | 11 | 4 | 4 | 2 | 3 | 21 | 2.57 | 1.00 | .220 |
| Andrew Miller | 14 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 10.0 | 7 | 3 | 3 | 0 | 5 | 17 | 2.70 | 1.20 | .194 |
| Ryan Dempster | 5 | 5 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 29.0 | 21 | 13 | 9 | 4 | 13 | 37 | 2.79 | 1.17 | .198 |
| Jon Lester | 4 | 4 | 3 | 0 | 0 | 0 | 0 | 1 | 1 | 29.0 | 19 | 10 | 9 | 1 | 3 | 20 | 2.79 | 0.76 | .181 |
| Clayton Mortensen | 10 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 14.0 | 10 | 7 | 7 | 1 | 9 | 8 | 4.50 | 1.36 | .204 |
| John Lackey | 3 | 3 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 16.1 | 21 | 13 | 9 | 2 | 5 | 15 | 4.96 | 1.59 | .300 |
| Felix Doubront | 7 | 6 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 37.1 | 46 | 25 | 25 | 2 | 22 | 42 | 6.03 | 1.82 | .307 |
| Alfredo Aceves | 4 | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 14.0 | 22 | 15 | 14 | 5 | 10 | 9 | 9.00 | 2.29 | .355 |
| Daniel Bard | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.0 | 1 | 1 | 1 | 0 | 2 | 1 | 9.00 | 3.00 | .250 |
| Allen Webster | 2 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 7.2 | 11 | 11 | 10 | 4 | 4 | 7 | 11.74 | 1.96 | .355 |
| Joel Hanrahan | 6 | 0 | 0 | 1 | 3 | 2 | 0 | 0 | 0 | 5.1 | 8 | 7 | 7 | 3 | 4 | 4 | 11.81 | 2.25 | .364 |
| Steven Wright | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.2 | 6 | 5 | 5 | 0 | 4 | 4 | 12.27 | 2.73 | .375 |