| Pitching | G | GS | W | L | SV | BS | HLD | CG | SHO | IP | H | R | ER | HR | BB | K | ERA | WHIP | BAA |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Totals | 157 | 66 | 65 | 19 | 64 | 173 | 3.53 | 1.33 | .248 | ||||||||||
| League Rank | T5 | T3 | T4 | T9 | T19 | 27 | 6 | T16 | 10 | ||||||||||
| José De La Torre | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.00 | 0.00 | .000 |
| Andrew Bailey | 4 | 0 | 0 | 0 | 2 | 0 | 2 | 0 | 0 | 3.1 | 1 | 0 | 0 | 0 | 1 | 5 | 0.00 | 0.60 | .091 |
| Craig Breslow | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.0 | 1 | 0 | 0 | 0 | 0 | 1 | 0.00 | 0.50 | .143 |
| Joel Hanrahan | 5 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 5.0 | 4 | 1 | 1 | 0 | 1 | 2 | 1.80 | 1.00 | .235 |
| Koji Uehara | 9 | 0 | 0 | 0 | 1 | 0 | 5 | 0 | 0 | 8.1 | 6 | 2 | 2 | 1 | 2 | 13 | 2.16 | 0.96 | .200 |
| Álex Wilson | 5 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 6.0 | 8 | 2 | 2 | 0 | 3 | 4 | 3.00 | 1.83 | .320 |
| Andrew Miller | 9 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 7.0 | 6 | 2 | 2 | 0 | 4 | 11 | 2.57 | 1.43 | .231 |
| Junichi Tazawa | 9 | 0 | 2 | 1 | 0 | 2 | 3 | 0 | 0 | 9.2 | 8 | 3 | 3 | 2 | 2 | 13 | 2.79 | 1.03 | .229 |
| Clay Buchholz | 3 | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 21.0 | 12 | 3 | 3 | 2 | 8 | 21 | 1.29 | 0.95 | .164 |
| Clayton Mortensen | 8 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 11.2 | 9 | 3 | 3 | 1 | 7 | 10 | 2.31 | 1.37 | .220 |
| Ryan Dempster | 2 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 11.0 | 9 | 4 | 4 | 2 | 7 | 12 | 3.27 | 1.45 | .231 |
| Alfredo Aceves | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 9.1 | 12 | 8 | 8 | 4 | 5 | 7 | 7.71 | 1.82 | .308 |
| John Lackey | 3 | 3 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 13.2 | 20 | 10 | 10 | 2 | 5 | 15 | 6.59 | 1.83 | .328 |
| Felix Doubront | 4 | 4 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 18.2 | 28 | 13 | 13 | 2 | 11 | 22 | 6.27 | 2.09 | .354 |
| Jon Lester | 6 | 6 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 38.0 | 33 | 15 | 14 | 3 | 8 | 35 | 3.32 | 1.08 | .224 |