| Pitching | G | GS | W | L | SV | BS | HLD | CG | SHO | IP | H | R | ER | HR | BB | K | ERA | WHIP | BAA |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Totals | 107 | 44 | 43 | 16 | 45 | 145 | 2.87 | 1.13 | .217 | ||||||||||
| League Rank | 4 | 3 | 3 | T13 | 10 | 25 | 2 | 1 | 2 | ||||||||||
| Jon Lester | 5 | 5 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 30.2 | 26 | 9 | 9 | 3 | 12 | 30 | 2.64 | 1.24 | .224 |
| Clay Buchholz | 4 | 4 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 31.0 | 19 | 4 | 4 | 0 | 12 | 29 | 1.16 | 1.00 | .181 |
| John Lackey | 3 | 3 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 16.1 | 11 | 4 | 3 | 1 | 3 | 17 | 1.65 | 0.86 | .183 |
| Junichi Tazawa | 6 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 0 | 5.1 | 8 | 2 | 2 | 1 | 0 | 4 | 3.38 | 1.50 | .364 |
| Andrew Bailey | 7 | 0 | 1 | 0 | 2 | 1 | 2 | 0 | 0 | 6.1 | 5 | 2 | 2 | 1 | 1 | 10 | 2.84 | 0.95 | .208 |
| Craig Breslow | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.00 | 0.00 | .000 |
| Koji Uehara | 7 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 7.0 | 5 | 1 | 1 | 1 | 2 | 8 | 1.29 | 1.00 | .200 |
| Clayton Mortensen | 5 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 6.1 | 5 | 2 | 2 | 1 | 1 | 9 | 2.84 | 0.95 | .208 |
| Álex Wilson | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.0 | 2 | 0 | 0 | 0 | 0 | 0 | 0.00 | 2.00 | .500 |
| Alfredo Aceves | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.2 | 3 | 3 | 3 | 1 | 2 | 5 | 7.36 | 1.36 | .214 |
| Ryan Dempster | 3 | 3 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 19.0 | 15 | 11 | 11 | 5 | 6 | 24 | 5.21 | 1.11 | .214 |
| Joel Hanrahan | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2.0 | 2 | 1 | 1 | 1 | 2 | 1 | 4.50 | 2.00 | .250 |
| José De La Torre | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.0 | 2 | 2 | 2 | 0 | 1 | 0 | 18.00 | 3.00 | .500 |
| Andrew Miller | 6 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 4.0 | 4 | 3 | 3 | 1 | 3 | 7 | 6.75 | 1.75 | .267 |