| Pitching | G | GS | W | L | SV | BS | HLD | CG | SHO | IP | H | R | ER | HR | BB | K | ERA | WHIP | BAA |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Totals | 195 | 83 | 80 | 22 | 83 | 202 | 3.45 | 1.33 | .246 | ||||||||||
| League Rank | 12 | 4 | 5 | T13 | 28 | 28 | 4 | T15 | 6 | ||||||||||
| Jose De La Torre | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.0 | 0 | 0 | 0 | 0 | 0 | 2 | 0.00 | 0.00 | .000 |
| Craig Breslow | 4 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 4.2 | 3 | 0 | 0 | 0 | 2 | 1 | 0.00 | 1.07 | .188 |
| Clay Buchholz | 4 | 4 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 28.0 | 17 | 4 | 4 | 2 | 11 | 25 | 1.29 | 1.00 | .177 |
| Koji Uehara | 11 | 0 | 0 | 0 | 1 | 0 | 7 | 0 | 0 | 10.1 | 8 | 2 | 2 | 1 | 3 | 18 | 1.74 | 1.06 | .211 |
| Joel Hanrahan | 5 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 5.0 | 4 | 1 | 1 | 0 | 1 | 2 | 1.80 | 1.00 | .235 |
| Clayton Mortensen | 10 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 13.1 | 11 | 3 | 3 | 1 | 8 | 10 | 2.03 | 1.43 | .229 |
| Andrew Bailey | 5 | 0 | 0 | 0 | 2 | 0 | 2 | 0 | 0 | 4.1 | 2 | 1 | 1 | 1 | 1 | 6 | 2.08 | 0.69 | .133 |
| Andrew Miller | 11 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 8.1 | 6 | 2 | 2 | 0 | 4 | 13 | 2.16 | 1.20 | .200 |
| Junichi Tazawa | 10 | 0 | 2 | 1 | 0 | 2 | 3 | 0 | 0 | 10.2 | 10 | 3 | 3 | 2 | 2 | 15 | 2.53 | 1.13 | .250 |
| Alex Wilson | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 9.2 | 11 | 3 | 3 | 0 | 4 | 7 | 2.79 | 1.55 | .289 |
| Jon Lester | 7 | 7 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 44.0 | 40 | 21 | 19 | 4 | 11 | 37 | 3.89 | 1.16 | .233 |
| John Lackey | 4 | 4 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 19.2 | 21 | 11 | 10 | 2 | 5 | 20 | 4.58 | 1.32 | .263 |
| Ryan Dempster | 3 | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 15.2 | 17 | 9 | 9 | 2 | 13 | 14 | 5.17 | 1.91 | .279 |
| Felix Doubront | 5 | 5 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 24.2 | 33 | 15 | 15 | 3 | 13 | 25 | 5.47 | 1.86 | .330 |
| Alfredo Aceves | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 9.1 | 12 | 8 | 8 | 4 | 5 | 7 | 7.71 | 1.82 | .308 |