| Pitching | G | GS | W | L | SV | BS | HLD | CG | SHO | IP | H | R | ER | HR | BB | K | ERA | WHIP | BAA |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Totals | 260 | 143 | 132 | 36 | 124 | 317 | 4.00 | 1.29 | .234 | ||||||||||
| League Rank | 3 | 6 | 6 | 11 | 18 | 21 | 17 | 17 | T3 | ||||||||||
| Álex Wilson | 10 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 11.1 | 10 | 1 | 1 | 0 | 6 | 7 | 0.79 | 1.41 | .238 |
| Andrew Bailey | 12 | 0 | 1 | 0 | 5 | 1 | 3 | 0 | 0 | 11.1 | 5 | 2 | 2 | 1 | 3 | 19 | 1.59 | 0.71 | .128 |
| Junichi Tazawa | 15 | 0 | 1 | 1 | 0 | 0 | 8 | 0 | 0 | 14.0 | 12 | 3 | 3 | 1 | 1 | 17 | 1.93 | 0.93 | .245 |
| Clay Buchholz | 8 | 8 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 58.2 | 42 | 13 | 13 | 2 | 21 | 61 | 1.99 | 1.07 | .203 |
| Jon Lester | 6 | 6 | 4 | 0 | 0 | 0 | 0 | 1 | 1 | 39.2 | 26 | 11 | 11 | 3 | 13 | 34 | 2.50 | 0.98 | .183 |
| John Lackey | 3 | 3 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 18.0 | 17 | 9 | 5 | 2 | 6 | 16 | 2.50 | 1.28 | .239 |
| Koji Uehara | 15 | 0 | 0 | 0 | 1 | 1 | 6 | 0 | 0 | 13.2 | 10 | 4 | 4 | 3 | 2 | 18 | 2.63 | 0.88 | .200 |
| Craig Breslow | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.0 | 3 | 2 | 1 | 0 | 1 | 2 | 3.00 | 1.33 | .231 |
| Ryan Dempster | 7 | 7 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 42.0 | 32 | 23 | 19 | 8 | 16 | 57 | 4.07 | 1.14 | .205 |
| Clayton Mortensen | 11 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 15.0 | 12 | 8 | 8 | 2 | 6 | 12 | 4.80 | 1.20 | .214 |
| Andrew Miller | 16 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 11.0 | 8 | 6 | 6 | 1 | 7 | 20 | 4.91 | 1.36 | .200 |
| Felix Doubront | 5 | 4 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 27.1 | 34 | 20 | 20 | 0 | 16 | 29 | 6.59 | 1.83 | .309 |
| Alfredo Aceves | 4 | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 14.0 | 22 | 15 | 14 | 5 | 10 | 9 | 9.00 | 2.29 | .355 |
| Daniel Bard | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.0 | 1 | 1 | 1 | 0 | 2 | 1 | 9.00 | 3.00 | .250 |
| Allen Webster | 2 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 7.2 | 11 | 11 | 10 | 4 | 4 | 7 | 11.74 | 1.96 | .355 |
| Steven Wright | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.2 | 6 | 5 | 5 | 0 | 4 | 4 | 12.27 | 2.73 | .375 |
| Joel Hanrahan | 6 | 0 | 0 | 1 | 2 | 2 | 0 | 0 | 0 | 4.1 | 7 | 7 | 7 | 4 | 5 | 4 | 14.54 | 2.77 | .350 |
| José De La Torre | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.0 | 2 | 2 | 2 | 0 | 1 | 0 | 18.00 | 3.00 | .500 |