| Pitching | G | GS | W | L | SV | BS | HLD | CG | SHO | IP | H | R | ER | HR | BB | K | ERA | WHIP | BAA |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Totals | 298 | 128 | 124 | 40 | 128 | 299 | 3.53 | 1.35 | .249 | ||||||||||
| League Rank | 13 | 4 | T7 | T22 | 28 | 27 | 6 | T16 | 7 | ||||||||||
| Craig Breslow | 9 | 0 | 1 | 0 | 0 | 0 | 4 | 0 | 0 | 8.2 | 4 | 0 | 0 | 0 | 3 | 8 | 0.00 | 0.81 | .138 |
| Pedro Beato | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.0 | 0 | 0 | 0 | 0 | 0 | 1 | 0.00 | 0.00 | .000 |
| Clay Buchholz | 5 | 5 | 4 | 0 | 0 | 0 | 0 | 1 | 1 | 33.0 | 19 | 4 | 4 | 2 | 12 | 29 | 1.09 | 0.94 | .170 |
| Koji Uehara | 17 | 0 | 0 | 0 | 1 | 0 | 9 | 0 | 0 | 16.1 | 9 | 3 | 3 | 2 | 3 | 27 | 1.65 | 0.73 | .158 |
| Clayton Mortensen | 13 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 16.0 | 12 | 3 | 3 | 1 | 8 | 12 | 1.69 | 1.25 | .211 |
| Joel Hanrahan | 5 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 5.0 | 4 | 1 | 1 | 0 | 1 | 2 | 1.80 | 1.00 | .235 |
| Andrew Miller | 16 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 14.0 | 11 | 3 | 3 | 1 | 8 | 22 | 1.93 | 1.36 | .212 |
| José De La Torre | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.1 | 2 | 1 | 1 | 1 | 3 | 5 | 2.08 | 1.15 | .143 |
| Franklin Morales | 3 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 8.1 | 6 | 2 | 2 | 1 | 3 | 5 | 2.16 | 1.08 | .214 |
| Junichi Tazawa | 16 | 0 | 2 | 1 | 0 | 3 | 4 | 0 | 0 | 16.2 | 17 | 5 | 5 | 2 | 2 | 20 | 2.70 | 1.14 | .266 |
| Álex Wilson | 8 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 12.1 | 14 | 4 | 4 | 0 | 5 | 9 | 2.92 | 1.54 | .286 |
| Ryan Dempster | 4 | 4 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 23.1 | 22 | 11 | 11 | 3 | 18 | 18 | 4.24 | 1.71 | .247 |
| John Lackey | 7 | 7 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 38.1 | 44 | 20 | 19 | 7 | 10 | 31 | 4.46 | 1.41 | .282 |
| Felix Doubront | 7 | 7 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 35.1 | 46 | 20 | 19 | 4 | 17 | 36 | 4.84 | 1.78 | .322 |
| Jon Lester | 10 | 10 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 60.0 | 63 | 37 | 35 | 8 | 22 | 53 | 5.25 | 1.42 | .265 |
| Alfredo Aceves | 4 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 15.1 | 16 | 9 | 9 | 5 | 9 | 10 | 5.28 | 1.63 | .271 |
| Andrew Bailey | 9 | 0 | 0 | 0 | 4 | 1 | 2 | 0 | 0 | 8.1 | 9 | 5 | 5 | 3 | 4 | 11 | 5.40 | 1.56 | .281 |