Baltimore Orioles
- 23-21,
- 3rd AL East
| Date | Opponent | Result | Win | Loss | Save |
|---|---|---|---|---|---|
| Sun, Apr 1 | Tampa Bay Rays vs Tampa Bay (S) | L 5 - 8 | |||
| Fri, Apr 6 | Minnesota Twins vs Minnesota (0-0) | W 4 - 2 | J. Arrieta | C. Pavano | J. Johnson |
| Sat, Apr 7 | Minnesota Twins vs Minnesota (0-1) | W 8 - 2 | T. Hunter | F. Liriano | |
| Sun, Apr 8 | Minnesota Twins vs Minnesota (0-2) | W 3 - 1 | J. Hammel | A. Swarzak | J. Johnson |
| Mon, Apr 9 | New York Yankees vs NY Yankees (0-3) | L 2 - 6 | I. Nova | B. Matusz | |
| Tue, Apr 10 | New York Yankees vs NY Yankees (1-3) | L 4 - 5 | C. Rapada | P. Strop | M. Rivera |
| Wed, Apr 11 | New York Yankees vs NY Yankees (2-3) | L 4 - 6 | R. Soriano | K. Gregg | M. Rivera |
| Fri, Apr 13 | Toronto Blue Jays @ Toronto (4-2) | W 7 - 5 | D. O'Day | D. Oliver | J. Johnson |
| Sat, Apr 14 | Toronto Blue Jays @ Toronto (4-3) | W 6 - 4 | L. Ayala | F. Cordero | J. Johnson |
| Sun, Apr 15 | Toronto Blue Jays @ Toronto (4-4) | L 2 - 9 | K. Drabek | B. Matusz | |
| Mon, Apr 16 | Chicago White Sox @ Chi White Sox (5-3) | W 10 - 4 | P. Strop | Z. Stewart | |
| Tue, Apr 17 | Chicago White Sox @ Chi White Sox (5-4) | W 3 - 2 | W. Chen | J. Danks | J. Johnson |
| Wed, Apr 18 | Chicago White Sox @ Chi White Sox (5-5) | L 1 - 8 | J. Peavy | T. Hunter | |
| Thu, Apr 19 | Chicago White Sox @ Chi White Sox (6-5) | W 5 - 3 | J. Hammel | G. Floyd | J. Johnson |
| Fri, Apr 20 | Los Angeles Angels @ LA Angels (4-9) | L 3 - 6 | J. Williams | B. Matusz | J. Walden |
| Sat, Apr 21 | Los Angeles Angels @ LA Angels (5-9) | L 3 - 6 | J. Weaver | J. Arrieta | |
| Sun, Apr 22 | Los Angeles Angels @ LA Angels (6-9) | W 3 - 2 | P. Strop | L. Hawkins | J. Johnson |
| Tue, Apr 24 | Toronto Blue Jays vs Toronto (10-6) | W 2 - 1 | T. Hunter | H. Alvarez | P. Strop |
| Wed, Apr 25 | Toronto Blue Jays vs Toronto (10-7) | W 3 - 0 | J. Hammel | K. Drabek | P. Strop |
| Thu, Apr 26 | Toronto Blue Jays vs Toronto (10-8) | W 5 - 2 | D. O'Day | C. Janssen | L. Ayala |
| Fri, Apr 27 | Oakland Athletics vs Oakland (10-10) | L 2 - 5 | B. McCarthy | J. Arrieta | G. Balfour |
| Sat, Apr 28 | Oakland Athletics vs Oakland (11-10) | W 10 - 1 | W. Chen | T. Ross | |
| Sun, Apr 29 | Oakland Athletics vs Oakland (11-11) | W 5 - 2 | P. Strop | G. Balfour | |
| Mon, Apr 30 | New York Yankees @ NY Yankees (12-9) | L 1 - 2 | H. Kuroda | J. Hammel | M. Rivera |
* if needed