Rodriguez did not join the team in Chicago for Tuesday’s 9-5 victory in the series opener, missing his first game of the season. He spent the day in Miami, where his wife gave birth to their second daughter Monday night.
The superstar third baseman strained his right quadriceps Sunday at Baltimore. He is expected to rejoin the Yankees (11-10) on Thursday.
“Obviously he has his little quad problem,” Yankees manager Joe Girardi said. “He’ll rejoin us Thursday. I don’t know if he’ll be able to play Thursday, we’ll just how he how the treatments go and how he responds to it.”
The Yankees won for the sixth time in their last seven games against the White Sox (11-8) by hitting three home runs Tuesday. Bobby Abreu hit his seventh career grand slam, Johnny Damon had a three-run homer and Jason Giambi added a solo shot for New York.
“The guys did a good job of getting on base and we scored eight of our runs off home runs,” Damon said. “When you are able to get a grand slam and a three-run homer, it makes things a lot easier.”
Chicago has alternated wins and losses in its last six games. A.J. Pierzynski, who is batting a team-high .344, homered and had two hits for the White Sox.
Vazquez (3-1, 3.20 ERA) looks for his fourth straight victory when he faces one of his former teams. Since leaving New York after his lone season with the Yankees in 2004, he is 1-1 with a 4.91 ERA in two starts against them.
The right-hander stretched his winning streak to three Friday when he gave up two runs over 6 1-3 innings in a 9-2 victory at Tampa Bay. He has pitched into the seventh inning in all three of his wins after lasting just five innings in his season debut April 2 at Cleveland.
Vazquez is 4-0 with a 2.65 ERA in his last five home starts, striking out 43 and walking just four in that span.
The Yankees will turn to struggling veteran Mike Mussina (1-3, 5.75), who tries to avoid a third straight loss. Mussina lasted a season-low three innings and allowed five runs and seven hits in a 7-5 home loss to Boston last Thursday.
The right-hander remained tied with Hall of Famer Bob Gibson for 42nd place on the career wins list at 251 after giving up two homers.
“I missed so bad a couple times that I can’t remember what I tried to do. It was just lousy,” Mussina said.
Mussina hasn’t had much success on the road against the White Sox since joining New York in 2001. He’s 1-4 with a 5.26 ERA in six starts at U.S. Cellular Field with the Yankees.
Pierzynski is hitting .371 (13-for-35) lifetime against Mussina while Jermaine Dye is batting .377 (20-for-53) against the veteran.