The teams have split the first two games, with the last-place Giants (33-43) winning 4-3 in 11 innings on Monday, and the second-place Padres (43-33) winning 3-2 in 10 on Tuesday.
Bonds started the first two games and went 2-for-6 with no homers, although he scored the winning run on Monday. The slugger remains six homers shy of tying Hank Aaron’s all-time mark.
He’s expected to get the day off on Wednesday, however, meaning he likely won’t get to face the pitcher he has his most career at-bats against.
Maddux (6-4, 3.84 ERA), who Bonds has 127 at-bats against, is looking for career win No. 340. He is second among active pitchers in career wins, trailing only the New York Yankees’ Roger Clemens, who went into his scheduled start on Wednesday with 349 victories.
Maddux allowed two runs and seven hits in six innings on Friday against the Boston Red Sox at Fenway Park, but was outpitched by Daisuke Matsuzaka in a 2-1 loss. It snapped a five-start unbeaten streak in which he was 3-0 with a 3.48 ERA.
The future Hall of Famer is 27-14 with a 2.90 ERA in 47 career starts against the Giants - the third most wins he has against any major league team. He’s 3-0 with a 2.84 ERA in his last three starts against them.
He’ll be one of a record seven 40-year olds starting games Wednesday in the majors.
“I guess it means it’s not a kid’s game anymore,” Maddux said. “It means the doctors are better now. The strength and conditioning coaches are better.”
Kouzmanoff was just 2-for-20 (.100) with one RBI in his previous six games.
“He’s been a resilient kid,” San Diego manager Bud Black said. “He’ll be the first to tell you he’s not happy with where his average is … I told him he’ll find a way to figure it out.”
The Padres won for the second time in seven games and ended the Giants’ three-game winning streak.
“We got the big hit today,” San Diego outfielder Mike Cameron said. “Yesterday they got the big hit. Dave Roberts got us a couple times but today were able to come back and get a big run.”
Cain allowed five runs and seven hits in five innings on Friday in a 7-3 loss to the New York Yankees. He walked four and failed to strike out a batter for the first time in 53 career starts.
The 22-year-old right-hander is 3-1 with a 1.96 ERA in seven career starts against the Padres, including 0-1 with a 2.77 ERA in two outings this year.