Moyer looks for his seventh straight win at Minnesota as the Mariners and Twins continue their three-game weekend series on Saturday.
The Twins (21-26) defeated Seattle 3-1 on Friday, with the 20-year-old Hernandez taking the loss.
The Mariners (22-28), who have dropped four straight road games, have just one run and nine hits in the last two contests.
Seattle has won just two of its last 10 games at Minnesota, but Moyer (2-4, 3.66 ERA) has not lost at the Metrodome since May 15, 1994.
The 43-year-old left-hander is 7-1 with a 3.38 ERA in 11 career starts at the Metrodome, and is 6-0 with a 2.66 ERA in his last seven starts there.
Moyer is 12-6 with a 3.15 ERA in 24 career starts overall against the Twins.
The 20-year veteran recorded just his second win of the season in his last start, allowing two runs and seven hits in six innings while walking a season-high four batters in the Mariners’ 8-6 victory over Baltimore on Monday.
He allowed two hits and a run in the first inning against the Orioles, and has allowed at least one first-inning run in four of his last six starts.
“I seem to be able to have a knack to test myself in the first inning. It’s a quick wake-up call. I got myself into the jam and I was able to get myself out,” Moyer said.
While Moyer will make his 496th career start, Twins rookie Boof Bonser (0-0, 1.50) will make his second.
Bonser had a solid major-league debut in a 5-3 loss to Milwaukee on Sunday. The 6-foot-4, 260-pound Bonser did not record a decision, and gave up one run and five hits over six innings, striking out eight.
The Brewers were 0-for-8 with runners in scoring position against the right-hander, and allowed only one run after allowing Milwaukee to load the bases with no outs in the first inning.
“Bonser threw the ball fantastic and that was fun to watch,” Minnesota manager Ron Gardenhire said. “His first start up here and we knew he would be a little nervous at the start, which he was. He misfired a little bit but once he got past that, he threw the ball super for us.”
The Twins have won four of their last six games after a season-high five-game losing streak. They have won six of their last nine home games.
Minnesota catcher Joe Mauer hit his fourth home run of the season on Friday, and is 11-for-22 with two homers and six RBIs in his last five games.
Second baseman Luis Castillo went hitless in his third straight game, and is just 2-for-22 (.091) in his last five. His batting average has dropped from .341 to .306 in that span.
Seattle’s Ichiro Suzuki went 1-for-4 Friday, and is just 5-for-29 (.172) in his last seven games at the Metrodome.