The Cardinals look to build on a rare win over their division rivals as they continue their three-game series at Busch Stadium.
The Cardinals beat the Cubs 6-4 on Monday for their third straight victory. St. Louis, which is 42-18 against the NL Central this season, improved to just 4-6 this season against Chicago.
The Cubs are the only team in the division with a winning record against the Cardinals, who own the best record in baseball.
Albert Pujols hit a go-ahead three-run homer for St. Louis, his first since Aug. 25. Pujols, among the NL leaders with 103 RBIs, had driven in only one run in his previous seven games despite going 9-for-25 in that span.
“Guys like Derrek Lee and Albert Pujols and other guys at the top, Miguel Cabrera, nobody throws the ball down the middle to them,” manager Tony La Russa said. “So they have to work hard to get everything, and they deserve all the credit.”
Jim Edmonds followed Pujols homer with a home run for the Cardinals, who opened a 10-game homestand after a 9-4 road trip.
Glendon Rusch will take the mound for Chicago on Tuesday, looking to snap a four-start losing streak. The 30-year-old left-hander, who is making his 42nd appearance and 15th start of the season, has lost six straight decisions and has not won since June 2.