Garcia is 11-4 with a 3.76 ERA this season, but just 2-3 with a 5.00 ERA in 10 starts at U.S. Cellular Field. The 29-year-old right-hander has posted a 2.81 ERA in 12 road starts.
The Venezuelan right-hander went 76-50 with a 3.89 ERA in 169 starts and one relief appearance for the Mariners from 1999-2004.
Garcia, who has won two straight decisions, will be trying to become the third 12-game winner on the White Sox. Right-hander Jon Garland is 15-5 and lefty Mark Buehrle is 12-4. Only the St. Louis Cardinals have three pitchers with at least 10 wins.
The White Sox used six pitchers and got a tiebreaking home run from Tadahito Iguchi as they avoided a three-game sweep with a 5-4 win over Toronto on Thursday.
Iguchi, who finished 2-for-3, is hitting .485 (16-for-33) over his last nine games and overall is batting a team-high .290.
“He was a great player in Japan,” said center fielder Aaron Rowand, who hit a three-run homer in the first inning. “They don’t always translate into great players over here, but a few of them have.”
The Mariners know all about talented Japanese players.
Seattle right fielder Ichiro Suzuki set the standard when he came to the United States and won both the AL MVP and Rookie of the Year awards in 2001. Suzuki set a major league record with 262 hits last season, but the speedy outfielder is having a down year.
Suzuki, a .335 career hitter, is hitless in a career-high 19 at-bats, dropping the five-time All-Star’s average from .316 to .303.
Suzuki went 0-for-4 with a strikeout in Seattle’s 7-3 loss to Detroit on Thursday.
The Mariners have lost two straight and five of their last seven games.