Garland, who had a career-high 12 wins in each of the last three seasons, is tied with Toronto’s Roy Halladay for the AL lead in wins. Garland is looking to remain perfect at home after going 5-0 with a 2.39 ERA over his first five starts at U.S. Cellular Field.
The 25-year-old right-hander gave up one run and six hits over seven innings last Friday in a 4-2 win at San Diego. He is 2-0 with a 3.29 ERA since losing his only two straight starts of the season.
“Nothing feels any different,” Garland said. “I just want to go out and give my team a chance. Things have been going my way this year and hopefully they’ll continue to go that way.”
This will be Garland’s second career start against Arizona. He lost to the Diamondbacks in 2003 after giving up seven runs and 10 hits over four innings.
Chicago is trying to avoid getting swept in a series for the first time this season. The White Sox suffered a 10-4 loss on Tuesday after falling 8-1 in the opener.
Manager Bob Melvin has given Tony Clark the start at designated hitter over the first two games, playing Chad Tracy at first base. Tracy is 5-for-9 in the series and Clark, who has excelled as a pinch-hitter this season, is 1-for-8.
“It makes our lineup a lot deeper,” Melvin said. “Being able to get he and Chad both in the lineup, we get a lot deeper. It seems like we have a chance to score in every inning.”
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