Toronto had its three-game winning streak snapped with a 7-2 defeat by Minnesota on Friday night.
Right-hander Dave Bush, still looking for his first win of the season, will get the start on Saturday.
Bush didn’t figure in the decision, a 9-6 win over Boston on Tuesday, allowing three runs and five hits over just three innings.
He’s hoping for a similar performance against the Blue Jays, against whom he allowed three runs and seven hits over eight innings, but was on the losing end of a 3-2 decison at the Metrodome on May 18. It was his first-ever appearance against the Twins.
Toronto is 1-3 against Minnesota this season, including losses in the last three meetings.
The Blue Jays have won the season series just twice in the last six years, and are just 10-14 at home against Minnesota since 1999.
Johan Santana, who had allowed a season-high seven runs in a 10-3 loss to the Blue Jays on May 17, allowed two runs and four hits, struck out eight and walked two.
Santana was 0-2 with a 7.13 ERA in his last three starts against the Blue Jays.
“Santana came back and showed how good he is, especially after they tagged him over there in Minnesota,” Stewart said. “He made some adjustments and made great pitches.”
Kyle Lohse will face the Blu Jays on Saturday, and he’s seeking to post his second straight victory over them this season. Lohse allowed two runs over six innings in a 3-2 Minnesota win at the Metrodome on May 18.