Hampton was tagged for a season-high five earned runs and eight hits over six innings in Tuesday’s 11-6 loss to Florida after not allowing more than three runs in any of his first five starts.
Hampton, who is still an impressive 14-2 in his past 20 starts dating to last July 4, pitched for Houston from 1994-99, posting a career-best 22-4 mark in his final season with the Astros.
The Braves have taken the first three games of this series and five of six from Houston this season, including a 4-1 victory Saturday. The Astros beat the Braves in five games in last year’s NL Division Series.
Julio Franco went 3-for-4 with his first home run of the season for the Braves, who have won four straight and 12 of 15 overall.
The Astros lost their 10th straight road game, and fell to 1-13 on the road. The franchise record for consecutive road losses is 13, set in 1990.
“It’s 10 losses, 10 stinking losses,” Astros manager Phil Garner said. “Streaks follow streaks, so when we get it turned around, it’s going to be one dandy coming our way.”