The Indians, who were within one game of the top spot in the AL Central three weeks ago, have lost 16 of 20 and are now 11 games behind first-place Minnesota.
Cleveland was shut down by Anaheim’s John Lackey on Sunday, managing just one unearned run in a 2-1 loss to the Angels.
Sabathia, who is 10-9 with a 4.20 ERA, has a 5.66 ERA in 10 starts since the All-Star break. The 6-foot-7 left-hander will almost certainly have his hands full with red-hot Suzuki.
The 2001 AL MVP comes into this series needing 34 hits in the final 26 games to break George Sisler’s single-season major league record of 257.
Suzuki has fared well against Sabathia in his career, batting .429 (9-for-21) with two doubles, a triple and a home run.
However, even with Suzuki being the toughest out in the majors, the woeful Mariners have still lost five in a row.
Suzuki hit a single off reliever Jon Adkins in the seventh and finished 1-for-4.
The Mariners are hoping right-hander Gil Meche can get them into the win column on Monday.
Meche, who will turn 26 on Wednesday, has pitched well for Seattle since being called up from Triple-A Tacoma on July 31, going 3-0 with a 3.80 ERA in seven starts.
Meche began the season 1-5 with a 7.06 ERA in 10 starts before getting sent down to the minors in early June.