The struggling right-handers will go head-to-head when the Cubs and Brewers continue their three-game set at Miller Park.
Since starting the season 7-4, Clement has dropped seven of eight decisions, his only win in that stretch a 3-1 victory over Milwaukee on July 26.
In his last start, a 5-4 loss to San Diego on Thursday, Clement allowed three hits and walked five over five scoreless innings.
Despite his struggles, Clement leads the Cubs with 155 strikeouts and is second on the team with a 3.18 ERA. Run support has been Clement’s biggest downfall, as the Cubs have averaged just 3.7 runs in his starts this season.
Sheets, meanwhile, is getting even less help from his teammates, just 3.18 runs of support per start.
The 26-year-old right-hander has dropped four straight decisions and is looking for his first win since July 10.
In his last start, a 4-2 loss to Atlanta on Thursday, Sheets struck out the last eight hitters he faced to finish with 13, but still suffered his ninth loss of the season.
“It wasn’t good enough,” said Sheets, who allowed four runs and seven hits over eight innings. “Strikeouts are fine, but strikeouts don’t overcome mistakes.”
The Cubs have dropped four of five and seven of 10, including a 3-1 defeat in the series opener on Tuesday.
Bill Hall had a two-run triple for last-place Milwaukee, which improved to 7-5 against Chicago this season. The loss left the Cubs 1 1/2 games behind wild card-leading San Francisco.
“I’m tired of losing. It’s frustrating,” Cubs manager Dusty Baker said.
Despite the win, the Brewers have lost nine of their last 13.
Victor Santos, who had lost five straight starts, allowed five hits, struck out six and walked one over 6 1-3 innings for his 10th win of the season.