Griffith, acquired from the New York Mets along with David Weathers for Richard Hidalgo on June 17, is making his first start of the season. The right-hander had been at Triple-A New Orleans since the trade, and got the call after right-hander Wade Miller went on the disabled list on Tuesday.
Griffiths was 1-4 with a 7.02 ERA in nine appearances, including six starts, with the Mets last year.
The Astros are trying for their third straight win over the Rangers after Friday’s 7-5 victory.
Morgan Ensberg homered and finished with three RBIs for Houston.
“I felt like I got a 400-pound gorilla off my back,” said Ensberg, who hit his first homer since Sept. 27. “But also I was happy about the timing. It was a combination of everything.”
Carlos Beltran went 0-for-4 with a strikeout and had his career-high 15-game hitting streak snapped. Beltran, acquired from Kansas City on June 24, had homered in three straight games and had hit .417 (10-for-24) in his first six games with the Astros.
“Tonight wasn’t my night,” Beltran said. “All I want to do is help this team win. In Kansas City, we were out of the race. But here, every game means something.”
The Astros scored more than five runs for only the fourth time in the past 30 games. The offensive slump has helped drop Houston all the way into fifth place in the NL Central, a big disappointment for a team with World Series hopes.
“Maybe this will be something that will spark us,” Brad Lidge said. “I hope this game was a turning point. All we need is for some guys like (Ensberg) to break out.”
Houston improved to 3-4 since Beltran’s arrival.
The Rangers got homers from Mark Teixeira and David Delluci, but lost for the fourth time in six games following a season-high eight-game winning streak.
Teixeira homered for the third time in five games while Dellucci has four RBIs in his last two.