They’ll give the ball to their ace right-hander to begin a three-game series against the Toronto Blue Jays at SkyDome.
Radke, whose 3.86 ERA is the lowest among Minnesota’s starters, has spent his entire 10-year career with the Twins, compiling a 119-112 record with a 4.31 ERA.
“When he’s on the mound, we always feel pretty good,” Twins manager Ron Gardenhire said.
Radke takes the mound just one day after the Twins were blanked 11-0 by the Chicago White Sox. Minnesota failed to complete the sweep, and had its five-game winning streak snapped.
The 31-year-old right-hander is 1-0 with a 1.71 ERA over his last three starts. He took a shutout into the ninth inning on Wednesday against visiting Seattle, but had to settle for a 4-3 victory.
The Twins had scored a combined two runs in Radke’s previous three starts, which spanned 20 innings.
“It’s nice to get some runs out there,” Radke said.
Monday’s game is a rematch between Radke and Toronto’s Ted Lilly, who won the earlier meeting on April 26. Lilly tossed a two-hitter as the Blue Jays rolled to a 6-1 victory, while Radke gave up four runs and 10 hits over seven innings.
Acquired in the offseason in the trade that sent outfielder Bobby Kielty to Oakland, Lilly has won his last two decisions despite posting a 4.09 ERA.
The 28-year-old left-hander is 2-1 with a 3.38 ERA in four career starts against Minnesota.
Carlos Delgado hit a two-run homer for Toronto, which won for just the second time in six games following a six-game winning streak.
Delgado, who had just three RBIs in his previous 13 games, is batting .380 (19-for-50) with five homers and 12 RBIs in his career against Radke.