Radke had won three straight decisions before suffering an 8-3 loss to the Indians on Thursday. Despite the loss, Radke is 3-1 with a 3.95 ERA over his last six starts.
Radke has struggled against Cleveland more than any other team during his nine-year career. The veteran righty is 5-15 with a 6.00 ERA in 25 career starts against the Indians.
Teammate Johan Santana stayed hot in August with eight strong innings and Matt LeCroy hit a three-run homer, leading Minnesota to an 8-2 win over Cleveland on Tuesday.
Santana struck out a season-high 10 and allowed eight hits. The left-hander is 3-0 this month and has given up just four earned runs in his last 30 innings.
With the win, the Twins pulled within 1 1/2 games of first-place Kansas City in the AL Central. It is the closest the defending division champs have been since July 2.
Casey Blake went 4-for-4 with a two-run homer for the Indians, who have lost three of four.
Cleveland will have left-hander Brian Anderson on the mound Wednesday. Anderson beat Radke on Thursday, improving to 9-9 this season. He is 2-0 lifetime against Minnesota despite a 4.88 ERA in five career starts.
STANDINGS: Twins - 3rd place, 1 1/2 GB, AL Central. Indians - 4th place, 11 1/2 GB, AL Central.
TWINS PROBABLE STARTER: Radke (8-10, 5.09 ERA). Radke was roughed up for five runs and nine hits in 6 1-3 innings of the loss to Cleveland on Thursday. Radke has yielded nine earned runs over his last two starts.
INDIANS PROBABLE STARTER: Anderson (9-9, 3.83 ERA). The southpaw held the Twins to one run and six hits over 8 1-3 innings Thursday.
OFFENSIVE LEADERS: Twins - Shannon Stewart, .311 avg. and 69 runs; Torii Hunter, 22 HRs and 82 RBIs; Cristian Guzman, 13 SBs. Indians - Milton Bradley, .321 avg., 56 RBIs and 17 SBs.; Blake and Matt Lawton, 15 HRs; Blake, 64 runs.
SEASON SERIES: Indians, 8-4.
STREAKS AND NOTES: Twins - OF LeCroy is 4-for-7 with two home runs lifetime against Anderson. … RHP Radke has yielded 26 homers in 25 starts. … LHP Eddie Guardado leads the Twins with 27 saves. He has converted seven of his eight save opportunities since the All-Star break. Indians - RHP Bob Wickman pitched for the first time since last August, throwing one scoreless inning at Double-A Akron as he attempts a comeback from elbow ligament replacement surgery. … OF Blake is batting .345 (19-for-54) with five home runs this season against Minnesota. … 1B Travis Hafner is 3-for-3 with a home run against Radke. Hafner hit for the cycle against Minnesota on Thursday.
ROAD/HOME RECORDS: Twins - 31-31 on the road; Indians - 32-32 at home.
INJURIES: Twins - OF Lew Ford (arm), 15-day DL; RHP Mike Fetters (hamstring), 60-day DL; LHP Eric Milton (elbow), 60-day DL. Indians - C Victor Martinez (ankle), 15-day DL; IF Omar Vizquel (knee), 15-day DL; OF Bradley (back), 15-day DL; RHP Jason Boyd (shoulder), 15-day DL; RHP Jason Bere (shoulder), 60-day DL; RHP Dave Elder (shoulder), 60-day DL; RHP Wickman (elbow), 60-day DL; RHP Mark Wohlers (elbow), 60-day DL; IF Ricky Gutierrez (back), 60-day DL; OF Ellis Burks (elbow), 60-day DL.