Loaiza is looking to join Seattle’s Jamie Moyer as the majors’ second 10-game winner.
Moyer is 10-2, but Loaiza has been the American League’s most consistent pitcher.
The veteran right-hander has held the opposition to two runs or fewer in 11 of his 13 starts. His 2.06 ERA leads the AL and ranks him second behind only Kevin Brown of the Los Angeles Dodgers (2.00) for the major league lead.
Loaiza, who is 9-2, has been dominant of late, sporting a 4-1 record and 1.97 ERA over his last seven starts.
The White Sox are hoping Loaiza can help them get back on track after they suffered an 8-4 loss to Barry Bonds and the San Francisco Giants on Sunday. Bonds hit a tying two-run homer in the ninth and Rich Aurilia had a pinch-hit grand slam later in the inning to secure the win.
The White Sox have lost eight of their last 12 overall.
The Padres have lost 21 of their last 28, and are just 8-23 on the road this season.
Trailing 3-0 after four innings, the Padres scored four runs in the fifth and five in the sixth to avoid being swept in their first series with the Indians.
“That was a big win for us,” said Klesko, back in Cleveland for the first time since the 1995 World Series when he hit three homers while playing for Atlanta. “I have great feelings about this place especially since that was the only year we (the Braves) won it.”
Mark Loretta had three RBIs Thursday for the Padres, who finally got their 20th win.
STANDINGS: Padres - 5th place, 22 GB, NL West. White Sox - 3rd place, 8 1/2 GB, AL Central.
PADRES PROBABLE STARTER: Kevin Jarvis (no appearances). Jarvis had been on the 60-day disabled list with an elbow strain since March 26. The right-hander went 2-4 with a 4.37 ERA in just seven starts last season.
WHITE SOX PROBABLE STARTER: Loaiza (9-2, 2.06 ERA). Loaiza allowed three runs and seven hits over seven innings, while striking out nine and walking none, in a 10-3 win over Los Angeles on Sunday. He is now 5-0 on the road and the opposition is hitting just .190 overall against him.
OFFENSIVE LEADERS: Padres - White, .301 avg.; Klesko, 12 HRs and 35 RBIs; Xavier Nady and White, 32 runs; Ramon Vazquez, 7 SBs. White Sox - Frank Thomas, .284 avg. and 14 HRs; Carlos Lee, 38 RBIs and 31 runs; Lee and Magglio Ordonez, 6 SBs.
INTERLEAGUE RECORDS: Padres - 3-6; White Sox - 4-5.
STREAKS AND NOTES: Padres - OF Brian Buchanan is 2-for-6 with a home run against RHP Loaiza. Buchanan has three home runs over the last four games. … San Diego’s 5.50 ERA is the second-highest mark in the NL. … The Padres have won only two of their last 10 series against AL teams. White Sox - 1B Paul Konerko is mired in a 2-for-38 slump. … 3B Joe Crede tied a career high with three hits on Thursday. … 2B D’Angelo Jimenez is tied for third in the AL with five triples.
ROAD/HOME RECORDS: Padres - 8-23 on the road; White Sox - 17-14 at home.
INJURIES: Padres - SS Vazquez (abdominal strain), 15-day DL; INF Lou Merloni (knee), 15-day DL; OF Jason Bay (wrist), 15-day DL; RHP Clay Condrey (oblique), 15-day DL; RHP Brandon Villafuerte (shoulder), 15-day DL; RHP Trevor Hoffman (shoulder), 60-day DL; LHP Kevin Walker (elbow), 60-day DL; OF Phil Nevin (shoulder), 60-day DL. White Sox - INF Willie Harris (shoulder), 15-day DL.