This totally depends on your league's stats. If it's skewed toward offense, the Semin / Nash side wins hands down. If hits and blocked shots are included, then the Neal / McDonagh side probably has some merit.
Ultimately, Nash and Semin are 70+ point players in a full NHL season, while Neal is an 80+ player and McDonagh is a 30+ point player. So it all depends on how important offense is in your league.