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I personally like Brown and Harvin over Wayne in the #2 spot. Brown has been getting just as many looks as Mike Wallace and Roethlisberger can get him the ball. Harvin has been busting his A-- this season and he gives you the way outside shot of getting points if he runs back a touchdown on a kickoff.

I can see why you'd play Wayne this week since the Colts are playing Jacksonville so I'd think about putting him in the flex spot but it would be down to those three for me.