My $.02 worth is that it depends on the dynamics of your league. Is this a rookie only draft? How many teams are there? If it's a larger league - non exclusively rookie draft (16 team or more teams), I would lean towards a QB like the first replier said. If it's a smaller league, you might want to draft a stud RB - but which RB depends on the scoring system. Is it PPR or not? If it's PPR, a lot people would lean towards Ray Rice. If it's a not PPR league, a lot of people would lean towards LeSean McCoy. Usually a league won't be won in the 1st round, but a bad 1st round pick can absolutely kill your chances. Good luck!