While 9 out of 10 times it's going to be Peterson... what are your scoring settings? Is a TD pass worth 4 points or 6? How many passing yards equal a point? Are you starting one QB or two? All of these questions can make it more likely to pick a top tier QB with your first round pick, rather than a top tier RB. But, if you were choosing a QB instead of a RB, go with Brees, not Brady. And, lastly, is it a PPR league? If so, Peterson isn't even the best running back available, it would be MJD. In a standard league, you choose Peterson. In a QB points heavy league, with PPR, you either choose the best receiving RB, or the best QB. The rest is up to you.