i would look at getting different SP. Webb, Oswalt, Harden, Sheets are all big time potential injury situations.
your ERA and WHIP should be fine, and Ks will be (as long as those mentioned above stay relatively healthy). Saves are a little dicey, Mo will get his 40, Wagner probably only 25 (due to potential time share) Franklin was a little shakey to end the year.
Wins may be your biggest problem, Haren should get you 12-14 wins, Hughes and Joba might bounce back and forth from the rotation and bullpen, Oswalt puts up decent numbers, but playing for the Astros has it's issues.