I'm going with Brandon Jacobs. Yes Jacobs has been out for most of the season so far but he rebounded well in last week's game against the Jets. 100 yards rushing and a touchdown. Unfortunately also one fumble. Reggie Bush has the potential to breakout in any game but New Orleans who had the number one offense last year is like dead last this year. Drew Brees cannot hit his receivers which doesn't help Reggies Bush because it doesn't open up the running game. Eli Manning is probably just as inconsistent as Drew Brees but lately the Giants offense has been on a roll. So I'd say if you want to gamble for a huge game in the future go with Bush otherwise i think Brandon Jacobs.