The San Francisco 49ers got killed last week in Seattle, 29-3. They are still licking their wounds, many of them in a quite literal fashion.
Despite entering the game with only one player — running back LaMichael James — listed on the injury report, they now have 10 in advance of their game with Indianapolis Colts.
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And these aren't just plebe backups we're talking about, either. Among them: Colin Kaepernick, All Pro guard Mike Iupati, plus the entire starting defensive line.
Kaepernick has a foot injury but appears fine; he practiced fully on Wednesday. Iupati did as well, but there's a little concern that his surgically repaired shoulder, which kept him out of the May and June OTAs, might be acting up.
But we also are treated to one of the odder-looking injury designations: defensive end Ray McDonald (ankle, ankle). Yep, that's right. Both his ankles are acting up, and that's how the NFL is telling you as much.
Nose tackle Ian Williams had only one ankle injury, but it was a devastating one. He's done for the season. Tight end Vernon Davis (hamstring) and James (knee) both missed practice. Those who were limited on Wednesday were linebackers Aldon Smith (back) and NaVorro Bowman (wrist) and rookie safety Eric Reid (concussion).
What a difference a few days made for the 49ers. They entered Sunday in good shape. Now they are beat up, and the Colts just added Trent Richardson in advance of Sunday. Gut-check time early in the season.